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For example, investigating whether certain co-administered compounds can mitigate receptor desensitization, thereby extending on-cycle periods, or if they necessitate shorter cycles due to additive effects

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Clinical safety and efficacy in humans have not been established

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In the initial stages of research into the heterogeneity of astrocyte responses, two distinct types of reactive astrocytes were identified: inflammatory/neurotoxic astrocytes, referred to as A1 astrocytes, and neuroprotective astrocytes, referred to as A2 astrocytes ( Astrocytes have been found to increase the expression of transmembrane receptors for IL-17 and TrkB in response to neuroinflammation